RE: How to code vomit event as absorption lag and lost of amount in administration comp.

Galadriel, could you turn the dose compartment off with an other event (EVID = 2, CMT = -1), then given another dose after that. ; E.G, with emesis at four hours: #ID TIME CMT AMT EVID IND  1 0   1 100 1   1 1 4 -1   . 2 0 1 4 1   100 1 2 $PK ; IF(IND.EQ.1) THEN F1 = THETA(1) ; FRACTION NOT LOST ALAG1 = THETA(2) ; NORMAL LAG ELSE F1 = (1-THETA(1))*THETA(3) ; THETA(3) IS REDUCED BIOAVAILABILITY ALAG1 = THETA(4) ; LAG AFTER EMESIS   END IF Other-Type Event: A positive value of CMT specifies a compartment to be turned on.   A negative value of CMT specifies a compartment to be turned off. When CMT is 0, no change is made in the status  of any compart- ment.   PCMT is the same as for dose events. Mark (aka Golum) Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185