RE: simulation of dose escalation study
From: mark.e.sale@gsk.com
Subject: RE: [NMusers] simulation of dose escalation study
Date: Mon, April 18, 2005 12:23 pm
Anthe,
The simulation seed can be accessed in the FCON file, which can be editted by a number of
methods, in the line SORC. This can be easily edited using macros (I prefer Excel, very
easy to write) Then, you don't have to recompile NONMEM, just run the executable again.
(I'll be happy to share code on how to do this if needed) Here is an FCON from simulation.
FILE FSTREAM
PROB example
DATA 1 0 0 10 0
ITEM 1 3 10 11 1 0 0 0 0 0 20 0 0
INDX 9 2 4 0 5 6 8 0 0 0 7
LABL ID TIME DV AMT SS II ADDL CMT EVID
MDV
IOB
VC LC
FORM
(9E5.0,1F2.0)
STRC 6 5 1 0 0 0 4 1 0
STRC 1 1 1 1 1 2 1 1
THCN 1 0 0 0
THTA .0167 83.7 0.651 1.33 1.16 0.0034
LOWR 0 0 -2 0-1000000 0
UPPR 1000000 1000000 1 1000000 1000000 1000000
BLST 0.0807
BLST 0.041
BLST 0.0829 -.0631 0.133
BLST 0.583
DIAG 1 0
SIML 0 1 0 0 1 0 0
SORC 061997622 0
TABL 1 2
TABL 1 4 1 0 2 0 30 0 9 0
0 1 1 0 0
TABL 1 4 1 0 2 0 32 0 33 0
0 1 1 0 1
And here is some simple Excel macro code to edit it with a new simulation seed
Public Sub set_fcon()
DoEvents
Open "fcon" For Input As #1
Open "fcon.new" For Output As #2
Dim line As String
While Not EOF(1)
Line Input #1, line
If Left(line, 4) <> "SORC" Then
Print #2, line
Else
Print #2, "SORC " & Format(Rnd() * 100000000, "000000000") & " " & 0
End If
Wend
Close #1
Close #2
FileCopy "fcon.new", "fcon"
End Sub
Mark Sale M.D.
Global Director, Research Modeling and Simulation
GlaxoSmithKline
919-483-1808
Mobile
919-522-6668
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