Re: NONMEM

From: Mark Sale - Next Level Solutions mark@nextlevelsolns.com Subject: Re: [NMusers] NONMEM Date: Thu, 14 Sep 2006 13:49:20 -0700 I agree with Steve, optimal design for studies is not generally available. Instead, we use simulation, to plagarize Steves term, to find a sufficient design by tweaking parameters and doing MC simulation. I would however, suggest that given sufficient computational power, formal optimization is possible on a reasonable time line - a couple of days. For most optimizations (i.e., BE studies, NCA pk studies, dose-response, survival etc), you won't use NONMEM anyway. You use SAS or Splus in some non-iterative alorithm (like ANOVA) that is very fast. So, for most trial optimizations, you don't need the (NONMEM) estimation, only the simulation. But, we currently don't have the tools to do this. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com