RE: PK models for rich and sparse sampling
From: mark.e.sale@gsk.com
Subject: RE: [NMusers] PK models for rich and sparse sampling
Date: Tue, June 1, 2004 10:28 am
I think someone (likely Nick), has pointed out that this has been in the literature.
Gisleskog PO. Karlsson MO. Beal SL. Use of prior information to stabilize a population data analysis.
Journal of Pharmacokinetics & Pharmacodynamics. 29(5-6):473-505, 2002 Dec.
I don't see a problem with publishing it, I don't think we have yet, but certainly intend to.
And you're right, we have found it to be a very powerful tool for constructing very large,
complex models that otherwise would not be stable (like PBPK models).
Mark