RE: $PK ADVAN6

Robert, This is ugly, someone else likely has a better solution, but it seems to work: control $PROBLEM Neg BOLUS $INPUT ID TIME AMT DV EVID CMT IND DROP $DATA DATA.PRN $SUB ADVAN6 TOL = 6 $MODEL COMP = (ONLY,DEFDOSE, DEFOBS) $THETA (0.06,FIXED) ;CL $OMEGA 0.5 $SIGMA 0.1 $PK " FIRST " COMMON /MYCOM/MYA " IF(IND.EQ.1) THEN " MYA = A(1) " END IF AT = MYA K = THETA(1)*EXP(ETA(1)) IF( IND.EQ.2.AND.AT.GT .20) THEN F1 = AT-20 ; assume 20 unit decrement in amount in compartment. ELSE F1 = 1 END IF $ERROR Y = F +ERR(1) AONE = A(1) $DES DADT(1) = -K*A(1) $SIM (1234) $TABLE ID TIME AMT DV MDV F1 AONE AT EVID IND NOPRINT FILE=OUT.DAT data file # ID TIME AMT DV EVID CMT IND CALL 1 0 80 . 1 1 0 0 1 0 . . 2 1 0 0 1 1 . . 2 1 0 0 1 2 . . 2 1 0 0 1 3 . . 2 1 0 0 1 4 . . 2 1 0 0 1 6 . . 2 1 0 0 1 6.4 . . 2 1 0 0 1 6.5 . . 2 1 0 0 1 6.6 . . 2 1 0 0 1 6.7 . . 2 1 0 0 1 6.8 . . 2 1 0 0 1 6.9 . . 2 1 0 0 1 7 . . 2 -1 1 2 1 7 1 . 1 1 2 2 1 7.1 . . 2 1 0 0 1 7.2 . . 2 1 0 0 1 7.3 . . 2 1 0 0 1 7.5 . . 2 1 0 0 1 8 . . 2 1 0 0 1 12 . . 2 1 0 0 1 24 . . 2 1 0 0 1 36 . . 2 1 0 0 1 48 . . 2 1 0 0 1 60 . . 2 1 0 0 turns out, you don't need the call data item. But, basically this remembers the amount in compartment 1 by putting it into a common (this won't work in NONMEM 7, BTW). Record (at time = 7) resets that compartment (CMT = -1). On the next record it uses that saved value (MYA or AT) to set F1 (to, in this case 20 units less than it was before) for the dose (also at time = 7). The negative bolus (20 in this case) could easily enough be read in from the data set. Hope this helps. Mark Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 A carbon-neutral company See our real time solar energy production at: http://enlighten.enphaseenergy.com/public/systems/aSDz2458 >> *From:* [email protected] >> [ mailto: [email protected] ] *On Behalf Of *Robert Kalicki >> *Sent:* Wednesday, September 01, 2010 8:47 AM >> *To:* [email protected] >> *Subject:* [NMusers] $PK ADVAN6 >> >> Dear NMusers >> >> I have an issue with coding my $PK block (in ADVAN6 (8)) for a >> particular situation. >> >> How could I code a punctual removal of a certain amount from a depot >> compartment between scheduled multiple doses without having recourse to >> an additional and punctual clearance? >> >> In other words, I would like to subtract a certain amount (i.e. >> "negative bolus", this amount would in fact appear as an individual >> parameter in the dataset) without working with rates and clearances? Is >> it possible? >> >> Let me know if you need additional information. >> >> Many thanks in advance. >> >> Best regards. >> >> Robert >> >> ___________________________________________ >> Robert M. Kalicki, MD >> >> Postdoctoral Fellow >> >> Department of Nephrology and Hypertension >> >> Inselspital >> >> University of Bern >> >> Switzerland >> >> Address: >> >> Klinik und Poliklinik für Nephrologie und Hypertonie >> >> KiKl G6 >> >> Freiburgstrasse 15 >> >> CH-3010 Inselspital Bern >> >> Tel +41(0)31 632 96 63 >> >> Fax +41(0)31 632 14 58 >> >> >> ------------------------------------------------------------------------ >> This e-mail (including any attachments) is confidential and may be >> legally privileged. If you are not an intended recipient or an >> authorized representative of an intended recipient, you are prohibited >> from using, copying or distributing the information in this e-mail or >> its attachments. If you have received this e-mail in error, please >> notify the sender immediately by return e-mail and delete all copies of >> this message and any attachments. >> >> Thank you. > > > This e-mail (including any attachments) is confidential and may be legally privileged. If you are not an intended recipient or an authorized representative of an intended recipient, you are prohibited from using, copying or distributing the information in this e-mail or its attachments. If you have received this e-mail in error, please notify the sender immediately by return e-mail and delete all copies of this message and any attachments. > > Thank you. >