RE: Software and procedures for conducting and reporting on NONME M analyses in clinical reports
From: "Sale, Mark" <ms93267@glaxowellcome.com>
Subject: RE: Software and procedures for conducting and reporting on NONME M analyses in clinical reports
Date: Wed, 31 May 2000 16:12:47 -0400
Dick,
My two cents worth on compiling NONMEM statistical output:
We use NONMEM a lot for simulation and Bootstrap as well as some semi automated analyses, using Excel macros as a front end. We've found that it is pretty easy to modify the Cfiles.for file to output all the info automatically. With Alisons and Stuarts permission I'd be happy to share this version of Cfiles.for with anyone. The output (written to a file called parms) for one run is given below. The number of thetas, etas and eps are needed in order to read the vectors and R squared matrix into the Excel macro (you need to know how many columns and rows to read in). Upper and lower limits are needed to test if the value of theta hit a boundary (there's probably a better way to do this, but I haven't found it)
Mark
OBJ 0.3797139E+03
SUCCESS 0 0
NUMBER OF THETAS
11 11
NUMBER OF ETAS AND EPS
3 2 2
NTHP,NETP,NEPP
LOWER BOUND AND UPPER BOUND
0.00000E+00 0.10000E+07
0.00000E+00 0.10000E+07
0.00000E+00 0.10000E+07
0.00000E+00 0.10000E+07
0.00000E+00 0.10000E+07
-0.10000E+01 0.10000E+01
0.00000E+00 0.10000E+07
0.00000E+00 0.00000E+00
-0.10000E+07 0.10000E+07
-0.10000E+07 0.10000E+07
-0.10000E+07 0.10000E+07
THETA
0.5903068E+01
0.4449646E+00
0.1790151E+03
0.3204727E+00
0.7880275E-01
0.6936011E+00
0.1101479E-01
0.0000000E+00
-0.8234533E-02
0.6420390E-02
-0.4426185E+00
SE THETA
0.2238780E+01
0.1237273E+00
0.4673713E+02
0.1235160E+00
0.5437505E-01
0.3821208E-01
0.8225896E-02
0.1000000E+11
0.1872639E-02
0.4723597E-02
0.2507842E+00
OMEGA
0.2867055E+01 -0.3069114E+00 0.0000000E+00
-0.3069114E+00 0.8495351E-01 0.0000000E+00
0.0000000E+00 0.0000000E+00 0.1041822E+00
SE OMEGA
0.1983845E+01 0.1810840E+00 0.1000000E+11
0.1810840E+00 0.1925736E-01 0.1000000E+11
0.1000000E+11 0.1000000E+11 0.2862607E-01
SIGMA
0.1107726E+00 0.0000000E+00
0.0000000E+00 0.1000000E-05
SE SIGMA
0.1674749E-01 0.1000000E+11
0.1000000E+11 0.1000000E+11
R^2 MATRIX
1.000 -0.878 0.716 -0.889 -0.876 -0.616 0.362 -0.071 -0.369 0.187
0.956 -0.730 -0.064 0.366 0.344 0.000
-0.878 1.000 -0.740 0.832 0.926 0.788 -0.359 0.066 0.505 -0.397
-0.894 0.784 0.068 -0.356 -0.341 0.000
0.716 -0.740 1.000 -0.746 -0.847 -0.530 0.335 -0.647 -0.059 0.175
0.674 -0.343 -0.367 -0.003 0.638 0.000
-0.889 0.832 -0.746 1.000 0.850 0.575 -0.044 0.055 0.263 -0.372
-0.881 0.540 0.395 -0.370 -0.382 0.000
-0.876 0.926 -0.847 0.850 1.000 0.745 -0.330 0.236 0.373 -0.225
-0.843 0.587 0.224 -0.166 -0.534 0.000
-0.616 0.788 -0.530 0.575 0.745 1.000 -0.104 0.009 0.591 -0.275
-0.640 0.521 0.103 -0.297 -0.327 0.000
0.362 -0.359 0.335 -0.044 -0.330 -0.104 1.000 -0.351 -0.133 -0.219
0.278 -0.391 0.420 -0.028 0.200 0.000
-0.071 0.066 -0.647 0.055 0.236 0.009 -0.351 1.000 -0.423 0.153
-0.008 -0.198 0.274 0.468 -0.440 0.000
-0.369 0.505 -0.059 0.263 0.373 0.591 -0.133 -0.423 1.000 -0.132
-0.374 0.570 -0.324 -0.590 0.013 0.000
0.187 -0.397 0.175 -0.372 -0.225 -0.275 -0.219 0.153 -0.132 1.000
0.442 -0.404 -0.189 0.281 -0.267 0.000
0.956 -0.894 0.674 -0.881 -0.843 -0.640 0.278 -0.008 -0.374 0.442
1.000 -0.794 -0.059 0.419 0.212 0.000
-0.730 0.784 -0.343 0.540 0.587 0.521 -0.391 -0.198 0.570 -0.404
-0.794 1.000 -0.386 -0.523 0.106 0.000
-0.064 0.068 -0.367 0.395 0.224 0.103 0.420 0.274 -0.324 -0.189
-0.059 -0.386 1.000 0.188 -0.346 0.000
0.366 -0.356 -0.003 -0.370 -0.166 -0.297 -0.028 0.468 -0.590 0.281
0.419 -0.523 0.188 1.000 -0.195 0.000
0.344 -0.341 0.638 -0.382 -0.534 -0.327 0.200 -0.440 0.013 -0.267
0.212 0.106 -0.346 -0.195 1.000 0.000
0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
0.000 0.000 0.000 0.000 0.000 0.000