RE: How to code vomit event as absorption lag and lost of amountin administration comp.

Let me revise that, the previous would give the same fraction as lost for any time point after dosing #ID TIME AMT CMT EVID IND 1 0 100 1 1 1 1 4 . -1 2 0 1 4 100 1 1 2 $PK IF(IND.EQ.1) THEN F1 = 1 ; DON'T NEED TO CHANGE THIS, AMT AFTER EMESIS WILL VANISH WITH CMT = -1 ALAG1 = THETA(1) ELSE F1 = EXP(TIME*(-KA))*THETA(2) ; EXP(TIME*(-KA)) SHOULD BE FRACTION REMAINING AT ; TIME =4, THEN SOME FRACTION OF THIS (THETA(2) ALAG1 = THETA(3) END IF I think this will put the full amount into CMT 1 at T=0, then have it vanish at T=4 (effectively reducing F1), then put the remaining fraction (EXP((TIME*(-KA))) back, put only some estimate fraction of it (THETA(2), and give it some different lag time - I think. I think it could be adapted easily enough for multiple emesis events. Alternatively, you could put the doses into seperate compartments, but this will get cumbesome if you have multiple emesis events. Mark Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 > -------- Original Message -------- Subject: [NMusers] How to code vomit event as absorption lag and lost of amount in administration comp. From: Galadriel <[EMAIL PROTECTED]> Date: Tue, July 22, 2008 7:13 am To: > > [email protected] > > Dear all, Could someone please give me some tips coding vomitting event as an absorption lag and bioavailability decrease? It's a single dose oral solution with slow absorption. From data I noticed that the time of vomitting was at least 4 hour after dose. Some subjects had mutiple vomitting events. The exposure was noticed a delay after each vomitting compared with non-vomit subject. I have very limit data, and need a good fiitting for the plasma concentration to focus on the pd model. Is there any similar model reported in the literature? Much appreciate for your help! Best regards, Galadriel