Pediatric brain scaling

Dear Colleagues, I'm working on a drug that is administered intrathecally to kids and adults. I'm interested in scaling pk from adults to kids (whose brains start out relatively large, compared to the body, but reach maximum size in the teens, then stop growing). I'm a little surprised that I can't find anything about dosing CNS drugs to peds, based on brain weight (and, ideally, brain clearance). Does anyone know of anything? thanks Mark Mark Sale M.D. Vice President, Modeling and Simulation Nuventra, Inc. (tm) 2525 Meridian Parkway, Suite 280 Research Triangle Park, NC 27713 Office (919)-973-0383 [email protected]<[email protected]> http://www.nuventra.com Empower your Pipeline CONFIDENTIALITY NOTICE The information in this transmittal (including attachments, if any) may be privileged and confidential and is intended only for the recipient(s) listed above. Any review, use, disclosure, distribution or copying of this transmittal, in any form, is prohibited except by or on behalf of the intended recipient(s). If you have received this transmittal in error, please notify me immediately by reply email and destroy all copies of the transmittal.