RE: How to code vomit event as absorption lag and lost of amount in administration comp.

Galadriel, could you turn the dose compartment off with an other event (EVID = 2, CMT = -1), then given another dose after that. E.G, with emesis at four hours: #ID TIME CMT AMT EVID IND 1 0 1 100 1 1 1 4 -1 . 2 0 1 4 1 100 1 2 $PK IF(IND.EQ.1) THEN F1 = THETA(1) ; FRACTION NOT LOST ALAG1 = THETA(2) ; NORMAL LAG ELSE F1 = (1-THETA(1))*THETA(3) ; THETA(3) IS REDUCED BIOAVAILABILITY ALAG1 = THETA(4) ; LAG AFTER EMESIS END IF Other-Type Event: A positive value of CMT specifies a compartment to be turned on. A negative value of CMT specifies a compartment to be turned off. When CMT is 0, no change is made in the status of any compart- ment. PCMT is the same as for dose events.Mark (aka Golum) Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 > -------- Original Message -------- Subject: [NMusers] How to code vomit event as absorption lag and lost of amount in administration comp. From: Galadriel <[EMAIL PROTECTED]> Date: Tue, July 22, 2008 7:13 am To: > > [email protected] > > Dear all, Could someone please give me some tips coding vomitting event as an absorption lag and bioavailability decrease? It's a single dose oral solution with slow absorption. From data I noticed that the time of vomitting was at least 4 hour after dose. Some subjects had mutiple vomitting events. The exposure was noticed a delay after each vomitting compared with non-vomit subject. I have very limit data, and need a good fiitting for the plasma concentration to focus on the pd model. Is there any similar model reported in the literature? Much appreciate for your help! Best regards, Galadriel