RE: Simulation of Steady state concentration of Phenytoin

From: Mark Sale - Next Level Solutions mark@nextlevelsolns.com Subject: RE: [NMusers] Simulation of Steady state concentration of Phenytoin Date: Sun, 11 Jun 2006 15:04:12 -0700 Varun, One option is to change the bioavailability. Set it to 1 initially, with a dose of 1000, then if you want to give 1100, just change bioavailability to 1.1, so you don't have to recreate the data set. I'm not aware of canned solution to doing this, I don't think that Trial Simulator will (but those who know it better may correct me). Personally, I'd write an Excel macro that would run NONMEM, read the results, then recreate a data set with a different dose. People more sophistocated than I am would probably do it in S plus. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com