Different OBJ after covariance with parallel and IMPMAP

I've notices several times that when using IMPMAP and Running parallel the "one more iteration for variance" will fail on one (or more) of the processes. When it does this, the OBJ will be lower than the last iteration of the parameter estimation. It seems that when this happens, NONMEM uses the default value (0) for OBJI for the data sent to that process, resulting in a lower OBJ. So, you can, in principle, rerun the model using the MSF and single process. But, interestingly, while the OBJ reported in the outfile files seems to be wrong, NONMEM will still report SEE etc. Can the SEE values in this case be believed? Mark Sale M.D. Senior Vice President, Pharmacometrics Nuventra Pharma Sciences, Inc. 2525 Meridian Parkway, Suite 200 Durham, NC 27713 Phone (919)-973-0383 [email protected]<[email protected]>