Re: Interpreting IOV

From: mark.e.sale@GSK.COM Subject: Re: [NMusers] Interpreting IOV Date: Fri, 16 Sep 2005 08:59:00 -0400 Pete, Standard medical problem, don't ask a question (get a lab test) if you don't know what you're going to do with the answer. Is this any different from testing the hypothesis that clearance is a function of astrological sign? Every once in a while (1 in 20) the answer will be yes. But, there are a few physiological explanations, including changes in protein binding - due to other drugs perhaps? or change in fluid status (due to inactivity of confinement?). Mark Sale M.D. Global Director, Research Modeling and Simulation GlaxoSmithKline 919-483-1808 Mobile 919-522-6668