Lewis B. Sheiner

118 messages, 1994–2004

Date Subject
? NONMEM Analysis for Future Bayesian Estimation technical
Feb 18, 1994 Unknown Dosing Histories technical
Aug 03, 1994 Modeling Rates and Effects of Drug X technical
Aug 03, 1994 Modeling Rates and Effects of Drug X technical
Sep 02, 1994 Intrepretation of Dosing Intervals technical
Oct 11, 1994 NONMEM FTP Repository technical
Nov 29, 1994 Standard Error in ka with Decreasing Data technical
May 20, 1997 Re: Concentration values below assay limits technical
May 20, 1997 Re: Concentration values below assay limits technical
Sep 26, 1997 arterio-venous modeling technical
Oct 23, 1997 Problem with multiple dose input technical
Oct 29, 1997 Log Normal data technical
Jan 22, 1998 time_to_event technical
Jan 24, 1998 Logistic Mixed models with NONMEM technical
Oct 06, 1998 Re: Residuals technical
Oct 08, 1998 Re: Post-hoc distributions technical
Oct 08, 1998 Re: Residuals technical
Oct 30, 1998 Re: Negative objective functions technical
Oct 30, 1998 Re: Negative objective functions technical
Nov 13, 1998 Re: Bioequivalence question technical
Nov 30, 1998 Re: Time-to-event technical
Dec 02, 1998 minimum objective function technical
Dec 07, 1998 Re: How to calculate confidential interval of a plasma conc. curve technical
Jan 07, 1999 Re: Dble exponential error model technical
Jan 07, 1999 Re: Dble exponential error model technical
Jan 08, 1999 Re: Dble exponential error model technical
Jan 12, 1999 Re: full covariance matrix technical
Feb 02, 1999 PRED v DV technical
Mar 03, 1999 centering variables technical
Mar 03, 1999 Re: centering variables technical
Mar 25, 1999 Re: comparing theta's technical
Mar 29, 1999 Re: comparing theta's technical
Jun 02, 1999 Re: Fortran errors technical
Jun 10, 1999 Re: time variant covariate ? technical
Jun 11, 1999 Re: Nagaraja technical
Jul 19, 1999 Re: Blank data points technical
Jul 19, 1999 Re: Analysis of sparse data technical
Jul 30, 1999 Re: BQL values, version 3 news
Jul 30, 1999 Re: BQL values, version 3 news
Aug 03, 1999 Re: Do we need BQL? technical
Sep 14, 1999 Re: Fitting 2 compartment first-order input PK/PD model. technical
Sep 17, 1999 Re: NONMEM Analysis Strategy technical
Sep 23, 1999 Re: Variance of the predictions of the etas. technical
Oct 05, 1999 Re: treatment of BQL technical
Oct 05, 1999 Re: treatment of BQL technical
Nov 03, 1999 Re: ADVAN3 TRANS3 Problem technical
Nov 04, 1999 Re: ADVAN3 TRANS3 Problem technical
Nov 12, 1999 Re: Computing std for secondary parms technical
Nov 12, 1999 Re: Standard error of 'secondary' parameters technical
Nov 12, 1999 Re: Standard error of 'secondary' parameters technical
Nov 17, 1999 Re: repeating cases technical
Nov 18, 1999 Re: Cross product matrix technical
Nov 21, 1999 Re: Prediction intervals technical
Nov 22, 1999 Re: Covariate Models Using Weight technical
Dec 17, 1999 Re: metabolite modeling technical
Feb 08, 2000 Optimal sampling points technical
Mar 10, 2000 Re: ADVAN4!!! technical
Mar 13, 2000 Re: Nested random effects with NONMEM? technical
Apr 21, 2000 Re: Model building algorithm technical
Apr 24, 2000 Re: Model building algorithm technical
Apr 25, 2000 Re: Model building algorithm technical
May 08, 2000 Re: Validation of models for categorical data technical
Jun 12, 2000 Re: Sample Size technical
Jul 21, 2000 Re: Response is sum of amounts technical
Aug 09, 2000 Re: [Fwd: CLIN PHAR STAT: Mixed Vs Fixed] technical
Sep 11, 2000 Re: missing data items technical
Sep 11, 2000 Re: missing data items technical
Sep 20, 2000 Re: An approach for imputing missing independent variable (covariate) technical
Sep 20, 2000 Re: An approach for imputing missing independent variable (covariate) technical
Sep 21, 2000 Re: An approach for imputing missing independent variable (covariate) technical
Sep 25, 2000 Re: Weight as Covariate technical
Sep 29, 2000 Re: Correct codes of modeling Michaelis-Menten elimination usingconcentration-time data technical
Sep 29, 2000 Re: Bayesian estimation technical
Sep 30, 2000 Re: Bayesian estimation technical
Nov 14, 2000 Re: msg from atul technical
Feb 08, 2001 Re: Maximizing coefficient of determination technical
Mar 30, 2001 Re: Bootstrap resampling! -> Randomization test technical
Apr 03, 2001 Re: Data Construct / ADVAN selection technical
Apr 28, 2001 Re: Exponent in sigmoid Emax model and ETA technical
May 03, 2001 Re: residual error model, endogeneous drug technical
May 17, 2001 Re: Mixture model at the IOV level? technical
Jun 26, 2001 Re: BQLs technical
Jul 02, 2001 Re: Missing covariates technical
Jul 02, 2001 Re: Missing covariates technical
Jul 02, 2001 Centering (was Re: Missing covariates) technical
Jul 03, 2001 Re: Centering (was Re: Missing covariates) technical
Jul 27, 2001 Re: PRED VS WRES technical
Aug 16, 2001 Re: Help: Non-positive semi-definite message technical
Sep 14, 2001 Re: logistic regression technical
Sep 15, 2001 FYI - MEM for binary response with one obs/individual technical
Sep 17, 2001 1 binary response/person technical
Sep 18, 2001 Re: 1 binary response/person technical
Oct 01, 2001 Re: 2-compartment model: V2 doesn't vary technical
Oct 01, 2001 Re: Multiple dose levels technical
Dec 21, 2001 Re: local minimum technical
Jan 13, 2002 censored data technical
Jan 28, 2002 Re: error models log domain technical
Feb 19, 2002 Re: Modeling of Blood flow data technical
Feb 27, 2002 Re: PD modeling question technical
Apr 02, 2002 Re: Significance? technical
Apr 02, 2002 Likelihood technical
Apr 03, 2002 Re: Significance? technical
Apr 18, 2002 Re: covariate significance technical
Apr 22, 2002 Re: nonmem technical
Apr 23, 2002 Re: When to do transformation of data? technical
May 02, 2002 Re: sequential PK/PD technical
May 17, 2002 Re: Placebo-corrected PD models technical
Jul 31, 2002 Re: Missing Gender (Categorical values) - my $0.02 technical
Aug 22, 2002 Re: Imputation of missing sex covariate technical
Aug 25, 2002 Re: Imputation of missing sex covariate technical
Oct 04, 2002 Re: OMEGA HAS A NONZERO BLOCK technical
Oct 07, 2002 Re: OMEGA HAS A NONZERO BLOCK technical
Oct 07, 2002 Re: OMEGA HAS A NONZERO BLOCK technical
Oct 08, 2002 Re: OMEGA HAS A NONZERO BLOCK technical
May 16, 2003 Re: Math problem technical
Jul 25, 2003 Re: initial condition model technical
Dec 17, 2003 Re: Nonmem model technical
Jan 10, 2004 RE: Fitting Data Below the Quantification Limit technical