Re: Math problem

From: Lewis B. Sheiner Date: May 16, 2003 technical Source: cognigencorp.com
From:"Lewis B. Sheiner" Subject:Re: [NMusers] Math problem Date:Fri, 16 May 2003 12:42:54 -0700 This may help: when you constrain a parameter in NONMEM to be between finite lower and upper bounds, I believe the program uses the arcsin transformation to enforce the constraint. If this is what is happening, and NONMEM is somehow running into a problem applying this transformation (which appears to be the case in your problem), then this is a NONMEM problem, not your problem, and the folks art Globomax should perhaps be asked to address it ... LBS.
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