Re: Math problem
From:"Lewis B. Sheiner"
Subject:Re: [NMusers] Math problem
Date:Fri, 16 May 2003 12:42:54 -0700
This may help: when you constrain a parameter in NONMEM to be between
finite lower and upper bounds, I believe the program uses the arcsin
transformation to enforce the constraint. If this is what is happening,
and NONMEM is somehow running into a problem applying this
transformation (which appears to be the case in your problem), then
this is a NONMEM problem, not your problem, and the folks art Globomax
should perhaps be asked to address it ...
LBS.