Intrepretation of Dosing Intervals

I think the following is correct: The LAST dose of a steady state series is given AT THE TIME of the SS record. So, for your q8h example, a level at 16:15 is 8:15h after the last of the steady-state series. Your non-regular-interval steady-state dose coding is almost right, but unfortunately a miss is as good as a mile. Each steady state as you now have it is REPLACING the last one, so at the time of your observation, only the last SS will be present - that is, the system will appear to have been given a dose of 200 q 24 hours, each day at 2200 hours, the last dose of the series having been given 9:59h before your observation. It should be coded as follows: Date Time Dose SS II DV 9/1/94 08:00 200 1 24 0 9/1/94 16:00 200 2 24 0 9/1/94 22:00 200 2 24 0 9/2/94 07:59 0 0 0 23 Note the SS=2 on the SS records after the first - this ADDS IN the SS solution for the corresponding SS pattern to the previous SS solution. This then coresponds to SS with doses at 0800, 1600 and 2200 each day, the last dose of this pattern having been given 2200 9/1/94, and hence, again 9:59h before your observation. Your last set of data records would generate a SS pattern of doses at 0600, 1400 and 2200 each day, the last one of these given at 2200 on 9/1/94, as previously. OK?