NONMEM FTP Repository
I have put the following directories in the master directory NONMEM on
PKPD.ICON.PALO-ALTO.MED.VA.GOV where they can be accessed by anonymous
FTP:
PKPD.DIR: Various control file(s) that implement PK/PD modeling
(+/- tolerance).
Simultaneous: fit Y{PK,PD} = PKPD-Model(X|theta{PK,P{D}))
Sequential: 1. fit Y{PK} = PK(X|theta{PK}), then
2. fit Y{PD} = PD(X,theta{PK}|theta{PD}).
LOGIST.DIR: Control file(s) for rpt'd measures logistic regression -
g(p(y{ij}=1|X)) = f(X{ij},theta) + eta{i} + eps{ij},
where y{ij} = 0 (no event), or 1 (event) in indiv i at occas j.
Control files here implement
f(X,theta) = gamma.log(dose) - gamma.log(D50),
which yields p(y=1|Dose) = Sigmoid Emax model.