Matt Hutmacher

63 messages, 1998–2015

Date Subject
Jun 24, 1998 Q:$DES with a lagged zero-order bolus dose technical
Jan 15, 1999 Two abosorption periods from a single dose?? technical
Mar 16, 1999 Translation from CL,V etc. to alpha, etc. technical
Sep 22, 1999 Variance of the predictions of the etas. technical
Oct 13, 1999 ? Emptying the Gall Bladder in NONMEM technical
Nov 15, 1999 RE: Simulations technical
Dec 09, 1999 RE: metabolite modeling technical
Dec 09, 1999 RE: metabolite modeling technical
Dec 10, 1999 RE: metabolite modeling technical
Nov 17, 2000 RE: 95% CI of parameter estimate technical
Nov 20, 2000 RE: 95% CI of parameter estimate technical
May 01, 2001 Suspicious CL/F vs. CLCR and SGOT values technical
May 07, 2001 RE: Unreasonable VSS estimate technical
May 17, 2001 Mixture model at the IOV level? technical
May 24, 2001 Slow Gradient Method. technical
May 25, 2001 Increasing the umber of sub-population in a mixture model technical
Jul 06, 2001 RE: Centering (was Re: Missing covariates) technical
Jul 09, 2001 RE: Centering (was Re: Missing covariates) technical
Jul 12, 2001 RE: Centering (was Re: Missing covariates) technical
Jul 27, 2001 RE: One vs two compartments technical
Nov 07, 2001 NMSEE GUIDE technical
Nov 12, 2001 FOCE objective function technical
May 17, 2002 RE: Placebo-corrected PD models technical
May 29, 2002 Calling a uniform random variable in NONMEM technical
Jul 12, 2002 RE: Wrong model technical
Apr 02, 2003 RE: Describing variability technical
May 20, 2003 RE: DV Simulation technical
May 22, 2003 RE: Poor PRED estimates technical
Aug 12, 2003 RE: Calculation of WRES... technical
Oct 22, 2003 Re: LLR test, AIC, BIC technical
Jan 06, 2004 Fitting Data Below the Quantification Limit technical
Jan 27, 2004 RE: simulation technical
Apr 08, 2004 Trouble with Verbatim code technical
Jun 11, 2004 RE: $OMEGA blocks and log-likelihood profiling technical
Aug 18, 2004 RE: Outliers and the FDA guideline technical
Aug 23, 2004 RE: Outliers and the FDA guideline technical
Nov 16, 2005 RE: Incorporating duplicate assays technical
Nov 21, 2005 RE: Incorporating duplicate assays technical
Jul 28, 2008 RE: FW: PPC technical
Sep 12, 2008 RE: modeling binary observations technical
Nov 17, 2008 RE: Very small P-Value for ETABAR technical
Dec 04, 2008 RE: Lapacian estimation without second derivatives? technical
Dec 10, 2008 RE: OFV higher with FOCEI than FO technical
Dec 11, 2008 RE: OFV higher with FOCEI than FO technical
Aug 06, 2009 RE: Steady state model technical
Sep 24, 2009 RE: FW: VPC appropriateness in complex PK technical
Dec 15, 2009 RE: $ERROR and LOGIT technical
Apr 07, 2010 RE: RES and WRES output with Beal's M3 method technical
May 28, 2010 RE: distribution assumption of Eta in NONMEM technical
Jul 06, 2010 RE: Constrain PD values using a logistic transformation technical
Mar 28, 2011 RE: Time-to-event analysis with $DES technical
Jul 11, 2011 RE: Confidence intervals of PsN bootstrap output technical
Jul 12, 2011 RE: Confidence intervals of PsN bootstrap output technical
Dec 22, 2011 RE: Truncated Emax technical
May 24, 2012 RE: VD as a fraction of another VD technical
Jun 13, 2012 RE: omega matrix - friendly suggestion technical
Nov 08, 2012 RE: RE: Proper way to handle the pre-first dose PK observation for non-endogenous drug technical
Aug 29, 2013 Time-varing covariate and renal function as a covariate technical
Sep 03, 2013 RE: Time-varing covariate and renal function as a covariate technical
Nov 25, 2013 RE: Getting rid of correlation issues between CL and volume parameters technical
Nov 26, 2013 RE: Getting rid of correlation issues between CL and volume parameters technical
Feb 07, 2014 Issues with Simulation technical
Nov 06, 2015 RE: eigenvalues technical