RE: One vs two compartments
From: "HUTMACHER, MATTHEW [Non-Pharmacia/1825]"
<matthew.hutmacher@pharmacia.com>
Subject: RE: One vs two compartments
Date: Fri, 27 Jul 2001 14:36:58 -0500
Pete,
"Design evaluation for a population pharmacokinetic study using clinical
trial simulations: a case study" by Kowalski, K and Hutmacher, M in Stats in
Medicine, Volume 20, 15 January 2001, page 75-92, may help. This paper
deals with the design, power, and bias of using a one-compartment
approximation to the 2 compartment model.
Hope that helps.
Matt