RE: simulation
From: "Hutmacher, Matt" - mhutmach@amgen.com
Subject: RE: [NMusers] simulation
Date: 1/27/2004 3:46 PM
Xiaofeng,
As Ken stated, it is a bit of work to try and get the covariance matrix of
estimates for the empirical Bayes predictions of the etas. If you are able
to use SAS (or know someone that does), it is much simpler to get the
standard errors you desire. These quantities are computed by the delta
method and can be output using a single line of code. However, if you have
a complex model or a nonstandard dosing history, it will require some effort
to program the model for fitting.
Matt
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