Issues with Simulation
Dear All,
Recently we were running some simulation/estimation using SUBPROBLEMS in
NONMEM 7.2. In these runs we were generating covariates using a random
distribution such as the following:
IF(ICALL.EQ.4) THEN
COV1 = function + range*PHI(ETA(5))
COV2 = function(COV1)*EXP(ETA(4))
ENDIF
TVKA = THETA(1)
KA = TVKA*DEXP(ETA(1))
TVCL = THETA(2)*(COV2/X)**THETA(7)
TVV = THETA(3)*(COV2/X)**THETA(8)
The NONMEM run completes, but a TABLE file is not output and the following
error is reported
0PROGRAM TERMINATED BY NP4F
PRED RETURNS DIFFERENT OUTPUTS WITH THE SAME INPUTS
MESSAGE ISSUED FROM TABLE STEP
How do we avoid this error and get a table file?
We looked at the archive, and found that Dennis Fischer had asked this
question previously, but we did not see any follow-up on how to solve the
problem. I do not remember having this issue with previous versions of
NONMEM.
Can anybody provide a solution to this problem? We would greatly appreciate
it.
Best,
Matt