RE: Placebo-corrected PD models
From: "HUTMACHER, MATTHEW [Non-Pharmacia/1820]"
Subject:RE: [NMusers] Placebo-corrected PD models
Date:Fri, 17 May 2002 12:19:19 -0400
Hello,
I am not sure I totally understand this thread, but it seems to me that is
to model the placbo data by including them in the response data set and not
to divide the response data through by the placebo data or by baseline.
This would be analgous to an analysis of covariance instead of a percent
change from baseline analysis. Then, one can build the model in a
hierachical sense and do hypothesis tests on such issues as is a covariate
needed to adjust for baseline and is the placebo component of the model a
function of time.
Matt