RE: BOV

From: "Nick Holford" Subject: RE: [NMusers] BOV Date: Thu, September 23, 2004 5:28 pm Ken, You might want to read the paper that Mats and Lewis wrote on the topic of BOV. Their conclusions include: "Analysis of two real data examples using this model reveals significant IOV in all parameters for both drugs and supports the simulation findings for the case that IOV is ignored: predictable biases occur in parameter estimates and previously nonexistent period effects are found." Karlsson MO, Sheiner LB. The importance of modeling interoccasion variability in population pharmacokinetic analyses. Journal of Pharmacokinetics & Biopharmaceutics 1993; 21(6):735-50 -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/