BOV

From: "Renee Ying Hong" yinghong@pharm.usyd.edu.au Subject: [NMusers] BOV Date: Mon, September 20, 2004 6:12 pm Dear all, Say, the basic structural PK model is Pi = TVP * EXP(ETAi) ; P is PK parameters CV% of P can be calculated as SQRT (ETAi). We know that: PPV = BSV + WSV ; PPV is the population parameter variability WSV can be approximated by BOV, therefore, Pi = TVP * EXP(BSV+BOV) = TVP * EXP(ETAi + ETA1 * OCC1 + ETA2 * OCC2 +......+ ETAn * OCCn) My question is how to calculate CV% of BSA and BOV after incoporating BOV into the PK parameter variability? Kind Regards, Renee