RE: BOV
From:"Liu, Qi" qi_liu@merck.com
Subject: RE: [NMusers] BOV
Date: Wed, September 22, 2004 10:03 pm
Hello Liang,
In orthogonal projection the goal is to minimize the orthogonal
distances from the data points to the fitted line (not necessarily
for the sum of residual distance to be 0). In regression analysis,
we often put constraints similar to yours on the fixed effects, but
rarely use these constraints on the random effects. Sometimes, in
mixed effect models, for some random effect for interaction terms
between fixed and random effect, its sum across the fixed effect
can be constrained to 0. But in this case, since both ai and bij
are random effects, I don't think it will apply. If you can explain
the reason why the constrains should work here, I will be very happy to learn.
Qi
Qi Liu
Department of Drug Metabolism
Merck & Co., Inc
WP75-100
Sumneytown Pike
West Point PA 19486
Tel: 215 652 4096
Fax: 215 993 3533