RE: BOV
From: fabrice_nollevaux@sgs.com
Subject: RE: [NMusers] BOV
Date: Wed, September 22, 2004 4:42 am
Dear Nick, dear Ken,
Perhaps a possibility to unify your points of view:
PPV1 = BSV
PPV2 = BSV + BOV1
PPV3 = BSV + BOV2
PPV4 = BSV + BOV3
Occasion 1 is then considered as the reference, BOVs are then reflecting the
difference in BSV between each other occasion and the reference.
This would allow to solve the apparent overparametrization pointed out by Ken
(here: 4 equations with 4 unknowns) and this is also coherent with the ANOVA
theory (with 4 occasions, you should have only 3 degrees of freedom available
for the estimation of the occasion component, i.e. only three occasion levels
can be estimated independently, the fourth one being fixed with regards to the
three others).
Thanks to share your opinion about this.
Fabrice
Fabrice Nollevaux, M.Sc.
Biostatistician
SGS Life Sciences, Wavre, Belgium
www.sgsbiopharma.com