RE: BOV
From:"Liang Zhao" zhao.80@osu.edu
Subject: RE: [NMusers] BOV
Date: Wed, September 22, 2004 2:11 pm
I have the same doubt as Mike for Yaning's simplified scenario (with BOV is the
same for all occasions). Based on my understanding, the design for both the
simplified scenario and complex scenario is the same as Mike suggested. In
this case, the BSV and BOV are not comfounded and they are all estimable.
Think about the equation system
CLij=CL+ai+bij. There are 8 unknowns (a1-a4 and b.1-b.4 in this case) and
8 equations in the system, surely all of them are estimable. I agree that
BOV in the complex scenario is unestimable.
Liang Zhao PhD
Division of Pharmaceutics
The Ohio State Univ.