RE: order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis?
From: bachmanw@globomax.com
Subject: RE: [NMusers] order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis?
Date: 9/26/2003 11:21 AM
Marc,
I know I'm just being a devil's advocate in this discussion, but, there is
an argument for (and precedent in other fields) for the "kitchen sink"
approach. In the past the argument against it was time consumption. In
favor, was the "throwing away data" argument if you didn't use information
that was collected at great expense.
Now, with the automation of many of these methods (WAM, GAM42, etc) and
distributed computing via clusters and grids, time is not as large a factor.
Marc, nice segway into my blatant plug - come see our poster at AAPS:
Use of a Linux Cluster with PDx-Pop and NONMEM V to Streamline Population
Pharmacokinetic Analysis
[sorry, the devil made me do it!]
Bill
ps - It's nice to see a discussion revival on nmuser's, I was beginning to
think our listserver was down!