order of covariate inclusion
From: pbonate@ilexonc.com
Subject: [NMusers] order of covariate inclusion
Date: 9/25/2003 12:06 PM
Is anyone aware of any studies showing whether the order of covariate inclusion
has any impact on the final model using a forward addition model development strategy?
For example, suppose you have weight, sex, and age as covariates and then test weight,
then age, and then sex in the model using the likelihood ratio test. Does this or
can this result in a different model than if you tested sex then age then weight?
Thanks,
pete bonate
Peter L. Bonate, PhD, FCP
Director, Pharmacokinetics
ILEX Oncology, Inc
4545 Horizon Hill Blvd
San Antonio, TX 78229
phone: 210-949-8662
fax: 210-949-8219
email: pbonate@ilexonc.com