Re: Problems with an apparent compiler-senstive model

From: Nick Holford n.holford@auckland.ac.nz Subject: Re: [NMusers] Problems with an apparent compiler-senstive model Date: Thu, 03 Aug 2006 20:41:05 +1200 Mark, Thanks for a good summary of the problem. Let me also make it clear that I also prefer to see that a model converges and the covariance step completes. But the absence of these features does not make the model results bad. I agree with you that it is not uncommon to find a model that makes biological sense failing to converge while some empirical function allows NONMEM to run the convergence step. I prefer biology over empiricism. So today I more or less ignore NONMEM's diagnosis of "success" and prefer to judge a model on its performance e.g. with a predictive check. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/