Problems with an apparent compiler-senstive model

From: "Tsai, Max" max.tsai@spcorp.com Subject: [NMusers] Problems with an apparent compiler-senstive model Date: Sat, 29 Jul 2006 18:08:18 -0400 I have been working on a poppk model. Basic run-of-the-mill two compartment model with 1st order absorption. When I run the model in NM on one machine, it converges and the estimates appear to be reasonable and GOF plots look good. When I attempt to run the same model on a second machine, the run blows up and the model run terminates. Same control stream and same dataset. The processor and windows operating system are different, but it does not appear to be important, based on some of the previous postings that I have read in the NM archives. So, the only important difference is that one computer is running Digital Compaq Fortran v6.0 and the other computer is running Digital Compaq Fortran v6.5. Also, the compiler options for the two systems are identical in NONMEM. Has anybody had experience with a model that was sensitive to the version of the fortran compiler that is been used? If so, what to do in this situation? Obviously a model that is not reproducible under different conditions is not very robust. How would you handle a model like this? Attempts to simplify or reparameterize the model have not been successful in obtaining consistent results. I hope that the collective minds of this experienced group can shed some light on this issue. Thanks. -Max Max Tsai, Ph.D. Associate Principal Scientist (DMPK) Schering-Plough Corporation 2015 Galloping Hill Road K-15-2-2650 Kenilworth, NJ 07033-0530 (: (908) 740-3911 : (908) 740-2916 *: max.tsai@spcorp.com