Re: Problems with an apparent compiler-senstive model

From: "Bonate, Peter" Peter.Bonate@genzyme.com Subject: Re: [NMusers] Problems with an apparent compiler-senstive model Date: Mon, 31 Jul 2006 10:00:29 -0400 Max, A few years ago I organized a study with about 30 different people. I gave them all 5 different models to run on Nonmem. Some were overparamaterized, others were not. I then compared their results. The results were presented at AAPS in 2002 or 2003, I don't remember exactly what year. There was a definite compiler-computer interaction. The results were really interesting. People got different error messages. Some models crashed, others did not. Even when the models minimized successfully, people got the same parameter estimates but got different standard errors. I have the poster as a pdf to anyone that wants it. Pete bonate Peter L. Bonate, PhD Genzyme Corporation Senior Director, Pharmacokinetics 4545 Horizon Hill Blvd San Antonio, TX 78229 USA peter.bonate@genzyme.com phone: 210-949-8662 fax: 210-949-8219