TVKa>TVKe or Ka>Ke?

From: Yaning Wang <yaning@ufl.edu> Subject: [NMusers] TVKa>TVKe or Ka>Ke? Date: 8/7/2003 11:37 AM Dear Rick: Based on the code provided about flip-flop, the constrain is to make sure every individual's Ka>Ke. Can we use the following code to "estimate" TVKA and its between-subject variability? The only problem will be the SE of TVKA, which can be approximated by delta method based on the SEs of theta1, theta2 and theta3. I know that this code cannot guarantee every subject's Ka>Ke. But with TVKa>TVKe, what is the chance of some individuals' Ka<Ke? CL=THETA(1)*EXP(ETA(1)) V=THETA(2)*EXP(ETA(2)) TVKE=THETA(1)/THETA(2) TVKA=TVKE+THETA(3) KA=TVKA*EXP(ETA(3)) Yaning Wang Department of Pharmaceutics College of Pharmacy University of Florida