RE: Ka>Ke?

From: Serge Guzy <GUZY@xoma.com> Subject: RE: [NMusers] Ka>Ke? Date: 8/11/2003 12:44 PM If you would use simulations to test how your population PK software is working, flip-flop will cause a bias in the final population estimates you will obtain. The final population distribution will not be similar to the one you began with and will depend heavily on the initial estimates you begin with. Flip-flop can cause also your final population not to follow normality (or log-normality) and bimodality is common when not taking account for potential flip-flop. Constraints (not acceptance-rejection but rather the one proposed in this forum) are therefore necessary to remove dependence between initial estimates and final estimates and at the same time performing a valid population analysis. Serge _______________________________________________________