RE: TVKa>TVKe or Ka>Ke?
From: Chuanpu Hu <chuanpu.2.hu@gsk.com>
Subject: RE: [NMusers] TVKa>TVKe or Ka>Ke?
Date: 8/7/2003 3:08 PM
I agree with Ken's comments. Currently it is what I usually do. That is,
I watch the initial estimates so that flip-flop does not occur at the
population level, then I check it at the individual level. I actually
have had instances where flip-flop does occur at the individual level
although not at the population level (this answers part of Yanning's
question), and at that point I had to constrain KA>KE at the individual
level. Luckily, absorption half life wasn't the focus of that modeling.
Chuanpu