Re: Ka>Ke?

From: Rik Shoemaker <RS@chdr.nl> Subject: Re: [NMusers] Ka>Ke? Date: 8/11/2003 4:06 AM Dear Nick, This sounds like a very good idea to me and solves my problem of obtaining estimates of not very usefull parameters. I'll certainly try it when the need arises. Thanks! I'm personally not that worried about Ka>Ke for some and the reverse for others; the point of the flip flop -as far as I understand- is that your curves are not capable of telling you if one is larger than the other (equally good fits can be obtained by reversing the two) and therefore the choice is almost arbitrary (at least not data driven, but rather driven by what you think your drug behaves like). If you do get better fits if you have reversal on the individual level, I would indeed assume there is something else going on... Rik