RE: simulation problem or bug

-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Leonid Gibiansky Sent: Tuesday, May 24, 2011 9:35 AM To: Fidler,Matt,FORT WORTH,R&D Cc: nmusers Subject: Re: [NMusers] simulation problem or bug Matt, I was able to specify parameters explicitly and run simulations. So my immediate problem is solved. I am still unsure what is the problem with the MSF run. Thanks Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566 On 5/24/2011 9:14 AM, Fidler,Matt,FORT WORTH,R&D wrote: > Leonid, > > I am unsure why this occurs. I would try the following though: > > - Change the seed number > - Rerun another control stream linked to the MSF output by the model and change the SIGDIG to match the number of significant digits obtained from your model and run MAXEVAL=0 to create a MSF to run the simulation from. (If you run your simulation in this manner) > - Specify the parameters explicitly, and then run the simulation. > - Run the simulation in another version of NONMEM > > Otherwise I'm out of ideas. > > Matt. > > -----Original Message----- > From: [email protected] [mailto:[email protected]] On Behalf Of Leonid Gibiansky > Sent: Monday, May 23, 2011 3:27 PM > To: nmusers > Subject: [NMusers] simulation problem or bug > > Dear All, > I am trying to run simulations starting from the msf file (nm 7.1). > I've done it multiple times for the current project without any > problems. BUT for one specific problem, I see a very strange behavior: > The simulation script runs just fine with SUBPROBLEMS=0 option, but > fails with any other value (including 1) with the following error: > > 0MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION > IN THE CONTROL STREAM AND INPUT MSF > > I am not sure whether it is important but the original run completed > with 134 (rounding error) estimation error and successful covariance > step (with UNCONDITIONAL option) > > Any ideas of what is the problem? > > Thanks! > Leonid > > -- > -------------------------------------- > Leonid Gibiansky, Ph.D. > President, QuantPharm LLC > web: www.quantpharm.com > e-mail: LGibiansky at quantpharm.com > tel: (301) 767 5566 > > > > > This e-mail (including any attachments) is confidential and may be legally privileged. If you are not an intended recipient or an authorized representative of an intended recipient, you are prohibited from using, copying or distributing the information in this e-mail or its attachments. If you have received this e-mail in error, please notify the sender immediately by return e-mail and delete all copies of this message and any attachments. > > Thank you. >