RE: simulation problem or bug
Leonid,
I am unsure why this occurs. I would try the following though:
- Change the seed number
- Rerun another control stream linked to the MSF output by the model and
change the SIGDIG to match the number of significant digits obtained from your
model and run MAXEVAL=0 to create a MSF to run the simulation from. (If you
run your simulation in this manner)
- Specify the parameters explicitly, and then run the simulation.
- Run the simulation in another version of NONMEM
Otherwise I'm out of ideas.
Matt.
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Leonid Gibiansky
Sent: Monday, May 23, 2011 3:27 PM
To: nmusers
Subject: [NMusers] simulation problem or bug
Dear All,
I am trying to run simulations starting from the msf file (nm 7.1).
I've done it multiple times for the current project without any
problems. BUT for one specific problem, I see a very strange behavior:
The simulation script runs just fine with SUBPROBLEMS=0 option, but
fails with any other value (including 1) with the following error:
0MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION
IN THE CONTROL STREAM AND INPUT MSF
I am not sure whether it is important but the original run completed
with 134 (rounding error) estimation error and successful covariance
step (with UNCONDITIONAL option)
Any ideas of what is the problem?
Thanks!
Leonid
--
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Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
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