RE: simulation problem or bug

From: Matt Fidler Date: May 24, 2011 technical Source: mail-archive.com
Leonid, I am unsure why this occurs. I would try the following though: - Change the seed number - Rerun another control stream linked to the MSF output by the model and change the SIGDIG to match the number of significant digits obtained from your model and run MAXEVAL=0 to create a MSF to run the simulation from. (If you run your simulation in this manner) - Specify the parameters explicitly, and then run the simulation. - Run the simulation in another version of NONMEM Otherwise I'm out of ideas. Matt.
Quoted reply history
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Leonid Gibiansky Sent: Monday, May 23, 2011 3:27 PM To: nmusers Subject: [NMusers] simulation problem or bug Dear All, I am trying to run simulations starting from the msf file (nm 7.1). I've done it multiple times for the current project without any problems. BUT for one specific problem, I see a very strange behavior: The simulation script runs just fine with SUBPROBLEMS=0 option, but fails with any other value (including 1) with the following error: 0MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION IN THE CONTROL STREAM AND INPUT MSF I am not sure whether it is important but the original run completed with 134 (rounding error) estimation error and successful covariance step (with UNCONDITIONAL option) Any ideas of what is the problem? Thanks! Leonid -- -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566 This e-mail (including any attachments) is confidential and may be legally privileged. If you are not an intended recipient or an authorized representative of an intended recipient, you are prohibited from using, copying or distributing the information in this e-mail or its attachments. If you have received this e-mail in error, please notify the sender immediately by return e-mail and delete all copies of this message and any attachments. Thank you.
May 23, 2011 Leonid Gibiansky simulation problem or bug
May 24, 2011 Matt Fidler RE: simulation problem or bug
May 24, 2011 Leonid Gibiansky Re: simulation problem or bug
May 25, 2011 Robert Bauer RE: simulation problem or bug
May 25, 2011 Leonid Gibiansky Re: simulation problem or bug
May 26, 2011 Robert Bauer FW: FW: simulation problem or bug
May 26, 2011 Marc Gastonguay Re: simulation problem or bug