RE: simulation question
Dear all,
PsN is useful tool for this purpose but I think that the functionality that
should be used is called "Stochastic Simulation and Estimation (SSE)". The
Bootstrap functionality is primarily used for obtaining parameter
uncertainties. A detailed userguide for the SSE functionality is presented
at the PsN webpage (see link below).
http://psn.sourceforge.net/PDF_docs/sse_userguide.pdf
Write to the PsN mailing list if you experience any troubles and need help
([email protected]).
Best regards,
Martin
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Sebastian Ueckert
Sent: Friday, February 06, 2009 10:51
To: Ethan Wu
Cc: [email protected]
Subject: Re: [NMusers] simulation question
Dear Ethan,
the simplest solution to solve your problem would be to use the bootstrap
command of PSN ( http://psn.sourceforge.net/). With PSN installed you would
simply do:
bootstrap final_model.mod -samples=200
PSN would take care of unsuccessful runs and provide a nice summary of the
individual estimates.
Best regards
Sebastian
On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <[email protected]> wrote:
Dear users,
I am trying to compare several specific PK/PD study designs by:
-- run 200 simulations with the final model (develope from original
dataset)
-- fit the final model to the 200 simulated dataset
To achieve above, I used $SIM SUBPROB=200 option
however, nonmem would completely stop after running into estimation
problem at one specific simulation/estimation cycles, for some designs it
stop even before 10th iterations.
Is there anyway nonmem could continue go on?
Or, does someone know alternative way to achieve the goal?
thanks