Betr.: Re: simulation question
Dear Ethan,
Have you tried removing the $ESTIMATION step and replace all values with your
final estimations? What does your result file say after termination?
Sincerely
Rob
>>> Sebastian Ueckert <[email protected]> 02/06/09 10:51 >>>
Quoted reply history
On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <[email protected]> wrote:
> Dear users,
> I am trying to compare several specific PK/PD study designs by:
> -- run 200 simulations with the final model (develope from original
> dataset)
> -- fit the final model to the 200 simulated dataset
> To achieve above, I used $SIM SUBPROB=200 option
> however, nonmem would completely stop after running
> into estimation problem at one specific simulation/estimation cycles, for
> some designs it stop even before 10th iterations.
> Is there anyway nonmem could continue go on?
> Or, does someone know alternative way to achieve the goal?
> thanks
>
>
>