Re: simulation question

Hi, I dont understand why this wasn't fixed in NONMEM VI. It was a well known bug in NONMEM V and has caused lots of grief for users. I hope the NONMEM VII developers have got this high on their list of NONMEM bugs that need to be fixed. Nick > > Dear users, I am trying to compare several specific PK/PD study designs by: -- run 200 simulations with the final model (develope from original dataset) > > > > -- fit the final model to the 200 simulated dataset > > To achieve above, I used $SIM SUBPROB=200 option > > > > however, nonmem would completely stop after running into estimation problem at one specific simulation/estimation cycles, for some designs it stop even before 10th iterations. > > > > Is there anyway nonmem could continue go on? > > Or, does someone know alternative way to achieve the goal? > > thanks -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford