RE: simulation question

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Sebastian Ueckert Sent: Friday, February 06, 2009 1:51 AM To: Ethan Wu Cc: [email protected] Subject: Re: [NMusers] simulation question Dear Ethan, the simplest solution to solve your problem would be to use the bootstrap command of PSN ( http://psn.sourceforge.net/). With PSN installed you would simply do: bootstrap final_model.mod -samples=200 PSN would take care of unsuccessful runs and provide a nice summary of the individual estimates. Best regards Sebastian On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <[email protected]> wrote: Dear users, I am trying to compare several specific PK/PD study designs by: -- run 200 simulations with the final model (develope from original dataset) -- fit the final model to the 200 simulated dataset To achieve above, I used $SIM SUBPROB=200 option however, nonmem would completely stop after running into estimation problem at one specific simulation/estimation cycles, for some designs it stop even before 10th iterations. Is there anyway nonmem could continue go on? Or, does someone know alternative way to achieve the goal? thanks -- The information contained in this email message may contain confidential or legally privileged information and is intended solely for the use of the named recipient(s). No confidentiality or privilege is waived or lost by any transmission error. If the reader of this message is not the intended recipient, please immediately delete the e-mail and all copies of it from your system, destroy any hard copies of it and notify the sender either by telephone or return e-mail. Any direct or indirect use, disclosure, distribution, printing, or copying of any part of this message is prohibited. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorized to state them to be the views of XOMA.