RE: simulation question
Dear Ethan,
Perl-speaks-NONMEM (PsN) is a free program developed by Uppsala Research
Pharmacometrics group. We recently added a module performing Stochastic
Simulations followed by re-Estimations (SSE). The purpose is to investigate
aspects related to simulation or estimation methods, models, study designs
or statistical inference. I think it will solve your problem.
You can download it here as well as find the sse userguide:
http://psn.sourceforge.net/
What it does compared to NSUB=X is to run all problems in parallel, so a
termination won't affect the others. And moreover it provides a summary with
computations like bias etc... A simple single command will do the simulation
and the re-estimation with the different designs: sse run1.mod -samples=200
-alt=run2.mod
You can contact me or my colleagues for more details.
Best regards,
Elodie
Elodie L. Plan, PharmD, MSc,
PhDstudent
*******************************************
Div. of Pharmacokinetics and Drug Therapy,
Department of Pharmaceutical Biosciences,
Faculty of Pharmacy, Uppsala University
Box 591 - 751 24 Uppsala - SWEDEN
Office +46 18 4714385 - Fax +46 18 4714003
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Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Ethan Wu
Sent: Thursday, February 05, 2009 11:19 PM
To: [email protected]
Subject: [NMusers] simulation question
Dear users,
I am trying to compare several specific PK/PD study designs by:
-- run 200 simulations with the final model (develope from original
dataset)
-- fit the final model to the 200 simulated dataset
To achieve above, I used $SIM SUBPROB=200 option
however, nonmem would completely stop after running into estimation
problem at one specific simulation/estimation cycles, for some designs it
stop even before 10th iterations.
Is there anyway nonmem could continue go on?
Or, does someone know alternative way to achieve the goal?
thanks