RE: simulation question

-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Nick Holford Sent: Friday, February 06, 2009 6:39 AM To: [email protected] Subject: Re: [NMusers] simulation question Hi, I dont understand why this wasn't fixed in NONMEM VI. It was a well known bug in NONMEM V and has caused lots of grief for users. I hope the NONMEM VII developers have got this high on their list of NONMEM bugs that need to be fixed. Nick >> Dear users, >> I am trying to compare several specific PK/PD study designs by: >> -- run 200 simulations with the final model (develope from original >> dataset) >> -- fit the final model to the 200 simulated dataset >> To achieve above, I used $SIM SUBPROB=200 option >> however, nonmem would completely stop after running >> into estimation problem at one specific simulation/estimation cycles, >> for some designs it stop even before 10th iterations. >> Is there anyway nonmem could continue go on? >> Or, does someone know alternative way to achieve the goal? >> thanks >> >> >> > -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford