RE: Simultaneous drug and metabolite POPPK
Alternatively, you can express the metabolites in microgram-equivalents of
the parent
Quoted reply history
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of [EMAIL PROTECTED]
Sent: Tuesday, February 13, 2007 15:02
To: Nmusers (E-mail); [EMAIL PROTECTED]
Subject: RE: [NMusers] Simultaneous drug and metabolite POPPK
I have a question for those who submitted these two examples - Did you
transform the data into micromolar quantities? It is not clear from the
examples. I have not done much parent/metabolite modeling (just lucky I
guess) but it seems to me that one would have to work in molar units for
these models to be valid. Can someone comment on this?
Mike
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Michael J. Fossler, Pharm. D., Ph. D., F.C.P.
Director
Clinical Pharmacokinetics, Modeling & Simulation
GlaxoSmithKline
(610) 270 - 4797
FAX: (610) 270-5962
Cell: (443) 350-1194
[EMAIL PROTECTED]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
---------------------------------------------------------
Legal Notice: This electronic mail and its attachments are intended solely
for the person(s) to whom they are addressed and contain information which
is confidential or otherwise protected from disclosure, except for the
purpose for which they are intended. Dissemination, distribution, or
reproduction by anyone other than the intended recipients is prohibited and
may be illegal. If you are not an intended recipient, please immediately
inform the sender and return the electronic mail and its attachments and
destroy any copies which may be in your possession. UCB screens electronic
mails for viruses but does not warrant that this electronic mail is free of
any viruses. UCB accepts no liability for any damage caused by any virus
transmitted by this electronic mail.