RE: Simultaneous drug and metabolite POPPK
Hello
This is a code + data example for an IV infusion,
PARENT = 1 = cpt1
METAB = 2 = cpt2
Regards
Saik
Saïk URIEN, MD, PhD
Directeur de Recherche, INSERM
Service de Pharmacologie
Centre René Huguenin
35 rue Dailly
F92210 St Cloud
Tel. 01 4711 1684
Fax 01 4711 1617
email : [EMAIL PROTECTED]
$PROB R IV INFUS
$INPUT ID TIME AMT RATE DV CMT MDV
$DATA DATA125.csv
$SUBROUTINE ADVAN6 TOL=3
$MODEL
COMP=(PARENT)
COMP=(METAB)
$PK
V1=THETA(1)*EXP(ETA(1))
CL=THETA(2)*EXP(ETA(2))
P12=THETA(3)*EXP(ETA(3))
K20=THETA(4)*EXP(ETA(4))
S1=V
KEL =CL/V
K12 =P12*KEL
K10 =KEL - K12
V2 = 1
$DES
DADT(1) = -(K10+K12)*A(1)
DADT(2) = K12*A(1) - K20*A(2)
$ERROR
C1=A(1)/V1
C2=A(2)/V2
IPRED = C1
IF (CMT.EQ.2) IPRED=C2
Y=C1*(1+EPS(1))+EPS(2)
IF (CMT.EQ.2) Y=C2*(1+EPS(3))+EPS(4)
$THETA (0,5);V
$THETA (0,10);CL
$THETA (0,.005,1);f12
$THETA (0,.01);K20
$OMEGA 0.4;oV
$OMEGA 0.4;oCL
$OMEGA 0.1;of12
$OMEGA 0.1;oK20
$SIGMA .4;sPp
$SIGMA 1;sPa
$SIGMA .4;sMp
$SIGMA .1;sMa
$EST METHOD=1 INTERACTION MAXEVAL=4500 PRINT=10 POSTHOC
$COV
$TABLE ID TIME CMT NOPRINT FILE=r
DATA CORRESPONDING TO THE CODE ABOVE
#ID TIME AMT RATE DV CMT MDV
1101 0 433.36 216.68 0 1 1
1101 1 0 0 11.84 1 0
1101 1 0 0 0.44 2 0
1101 2 0 0 41.17 1 0
1101 2 0 0 1.05 2 0
1101 2.08 0 0 21.08 1 0
1101 2.08 0 0 0.91 2 0
1101 2.25 0 0 11.78 1 0
1101 2.25 0 0 0.82 2 0
1101 2.5 0 0 6.38 1 0
1101 2.5 0 0 0.6 2 0
1101 3 0 0 1.48 1 0
1101 3 0 0 0.26 2 0
1101 4 0 0 0.17 1 0
1101 4 0 0 0.06 2 0
1101 6 0 0 0.02 1 0
1102 0 1132.65 566.32 0 1 1
1102 1 0 0 33.49 1 0
1102 1 0 0 1.17 2 0
1102 2 0 0 38.02 1 0
1102 2 0 0 1.65 2 0
1102 2.08 0 0 45.7 1 0
1102 2.08 0 0 1.77 2 0
1102 2.25 0 0 46.49 1 0
1102 2.25 0 0 3.22 2 0
1102 2.5 0 0 40.18 1 0
1102 2.5 0 0 1.82 2 0
1102 3 0 0 13.41 1 0
1102 3 0 0 1.22 2 0
1102 4 0 0 2.7 1 0
1102 4 0 0 0.46 2 0
1102 6 0 0 0.12 1 0
1102 6 0 0 0.09 2 0
-----Message d'origine-----
Quoted reply history
De : [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] la part de Vijay V. Upreti
Envoyé : lundi 12 février 2007 19:20
À : [email protected]
Objet : [NMusers] Simultaneous drug and metabolite POPPK
Dear NMusers,
I have plasma concentration versus time data for a drug and its active
metabolite. I would like to simulataneously fit this drug and its metabolite
using NONMEM to obtain estimates of prameters and associated variability for
both drug and its active metabolite. I am sure guys have done this nicely in
past. I was wondering if someone can share a control stream and sample data
for my guidance.
Thanks
_______________
Vijay V Upreti
PhD Candidate
Pharmacokinetics-Biopharmaceutics Laboratory
Dept. of Pharmaceutical Sciences
University of Maryland, School of Pharmacy
Rm S509, 20 Penn St., Baltimore, MD 21201
Voice: 410.706.7388; Fax: 410.706.5017
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