RE: Simultaneous drug and metabolite POPPK
I think the easiest and least confusing way is to transform all concentrations
into molar units in your data sets at the beginning when you model parent and
metabolites simultaneously. However, there are other options to go around this
issue. For example, you can also incorporate molecular weights into your model
if you have to use weight concentrations in your data set for some reason.
Alan
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-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] Behalf Of [EMAIL PROTECTED]
Sent: Tuesday, February 13, 2007 9:02 AM
To: Nmusers (E-mail); [EMAIL PROTECTED]
Subject: RE: [NMusers] Simultaneous drug and metabolite POPPK
I have a question for those who submitted these two examples - Did you
transform the data into micromolar quantities? It is not clear from the
examples. I have not done much parent/metabolite modeling (just lucky I guess)
but it seems to me that one would have to work in molar units for these models
to be valid. Can someone comment on this?
Mike
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Michael J. Fossler, Pharm. D., Ph. D., F.C.P.
Director
Clinical Pharmacokinetics, Modeling & Simulation
GlaxoSmithKline
(610) 270 - 4797
FAX: (610) 270-5962
Cell: (443) 350-1194
[EMAIL PROTECTED]
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