RE: posthoc step
From: "Ludden, Thomas (MYD)" luddent@iconus.com
Subject: RE: [NMusers] posthoc step
Date: Thu, December 16, 2004 4:14 pm
Nick,
I believe there is just one ETA search algorithm in each version of NONMEM,
but let me confirm by tracing a simple example. I will let you know what I
find.
The ETA search in recent versions of NONMEM VI beta (since about June, 2003)
appears to be more stable than the one in NONMEM V. NONMEM VI beta does not
appear to produce the "spikes" in OFV due to inappropriate ETA estimates
that are sometimes seen with V. However, Jerry's example is a problem for
both versions.
Tom