RE: posthoc step
From: "Wang, Yaning" WangYA@cder.fda.gov
Subject: RE: [NMusers] posthoc step
Date: Tue, December 7, 2004 3:50 pm
Emperical Bayes Estimate is very typical in mixed effect modeling. Maybe you
should start with linear mixed effect modeling to get familiar with the
concept first before dealing with nonlinear mixed effect modeling where
various estimation methods may confuse you even further. Reading some basic
statistic books about mix effect modeling (Marie Davidian and David
Giltinan, or Geert Molenberghs and Geert Verbeke) and
Bayesian Analysis (Andrew Gelman, John B. Carlin, Hal S. Stern, and Donald
B. Rubin) will help.
Yaning Wang, PhD
Pharmacometrician
OCPB, FDA