RE: Non-physiological parameters at lowest OBJ

From: Atul Bhattaram <BhattaramA@cder.fda.gov> Subject: RE: [NMusers] Non-physiological parameters at lowest OBJ Date: 8/5/2003 9:45 AM Hello Justin You can do log-likelihood profiling and look at the surface for the local minima etc. It is logical to go with the model which gives physiologically relevant parameters. You may be able to justify the constraining of the parameters after looking at the log-likelihood profile. Venkatesh Atul Bhattaram CDER, FDA.