RE: Non-physiological parameters at lowest OBJ
From: Ron A.A. Matht <r.mathot@erasmusmc.nl>
Subject: RE: [NMusers] Non-physiological parameters at lowest OBJ
Date: 8/6/2003 9:02 AM
Hi Justin
In case 1 you're dealing with flip-flop kinetics: Ka < Ke
This situation should be avoided and is furthermore in contrast with
the fact that you know that the drug has a long elimination half life.
Flip-flop kinetics can be circumvented by defining Ka as follows:
TVKA=CL/V + THETA(1)
KA=TVKA*EXP(ETA(1))
On basis of the above your Ka will be constrained to be greater
than Ke.
Regards,
Ron
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Ron A.A. Matht, PharmD, PhD
Department of Clinical Pharmacy and Clinical Pharmacology
Erasmus MC
University Medical Center Rotterdam
PO Box 2040
3000CA Rotterdam
The Netherlands
Tel 31-10-4633202
Fax 31-10-4366605
E-mail: r.mathot@erasmusmc.nl